Interventional Psychiatry · Single-Day Protocol
ONE-Day TMS
An entire course of TMS delivered in one day. ONE-Day TMS combines 20 short sessions of intermittent theta-burst stimulation (iTBS) with a single, one-time medication dose designed to enhance the brain's ability to change — so patients who can't commit to weeks of daily visits still have a path to TMS.
How It Works
What is ONE-Day TMS?
Standard TMS usually means a session every weekday for six weeks or more. ONE-Day TMS is based on the ONE-D (Optimized, Neuroplastogen-enhanced Depression) regimen developed by TMS researchers to compress that course into a single clinic day.
- Efficient stimulation. iTBS delivers a full TMS dose in about three minutes instead of 20–40.
- Spaced sessions. Sessions repeat about every 30 minutes, an interval chosen to let the brain consolidate each round.
- Neuroplasticity support. A single pre-treatment dose of d-cycloserine and, when appropriate, lisdexamfetamine helps the brain respond. You don't start a new daily medication.
At a glance
- Non-invasive; you're awake the whole time
- Completed in one visit at our office
- Monitored by our clinical team all day
- Ongoing follow-up with your Mindspring psychiatrist
- Works alongside your current medication and therapy plan
What to Expect
Your treatment day
- Arrival and check-in. Vitals, a symptom rating scale, and a final safety review with the clinical team.
- Pre-treatment medication. You take the single neuroplasticity-support dose about an hour before the first session.
- Motor threshold and coil positioning. Our team calibrates the device to you and positions the coil over the target area of the prefrontal cortex.
- 20 iTBS sessions. Each lasts about three minutes, with roughly 30-minute breaks to rest, read, work, or eat. Plan on a full day, typically 10–11 hours.
- Discharge with a driver. Because of the medication and the length of the day, you'll need someone to drive you home.
- Follow-up. Improvement often builds over the following weeks. Your psychiatrist tracks progress with scheduled follow-ups and rating scales.
Candidacy
Who may be a good fit
- Adults with major depressive disorder who haven't responded adequately to antidepressants
- People who can't take weeks off work, school, or caregiving for daily TMS
- Patients traveling from outside Atlanta who need a single-visit option
- Those wanting a non-invasive option before or alongside other interventional care
Safety Screening
When it may not be right
- Non-removable metal in or near the head (aneurysm clips, cochlear implants, implanted stimulators)
- History of seizures or epilepsy
- Uncontrolled cardiovascular conditions, or contraindications to the pre-treatment medications
- Active psychosis, mania, or substance use requiring a higher level of care
- Pregnancy, unless reviewed specifically with your psychiatrist
This isn't a complete list — your evaluation includes a full TMS and medication safety screen.
Evidence
What the research shows so far
Single-day TMS is an active research area. In early published case series of the ONE-D regimen, every patient completed all 20 sessions on schedule without serious adverse events, and most experienced meaningful improvement that increased over the following 4–6 weeks. A larger matched comparison released as a preprint in 2026 reported higher response and remission rates with single-day TMS than with standard once-daily TMS.
Compare Protocols
How ONE-Day compares
| Protocol | Schedule | Sessions | Time in office | Medication add-on | FDA status |
|---|---|---|---|---|---|
| ONE-Day TMS | 1 day | 20 iTBS | ~10–11 hrs in clinic | Single pre-treatment dose | Off-label |
| Accelerated TMS | 1–2 weeks | Up to ~40 iTBS | ~2–4 hrs/day | None | Off-label schedule |
| Standard rTMS | ~6 weeks + taper | ~30–36 | ~20–40 min/day | None | FDA-cleared for MDD |
Schedules are typical; your psychiatrist sets the final protocol. Mindspring Health is self-pay and does not bill insurance — see the Fees page for current pricing. We can provide a superbill for possible out-of-network reimbursement, but reimbursement isn't guaranteed.
Physician-Led Care
Overseen by a board-certified psychiatrist
Dr. A. Umair Janjua, M.D., FAPA, founded Mindspring Health and oversees its interventional psychiatry program. Every interventional treatment is reviewed with you by a psychiatrist before it becomes part of your plan, and monitored and adjusted the same way the rest of your care is.
Common Questions
Frequently Asked Questions
Is ONE-Day TMS FDA-approved?
TMS devices are FDA-cleared for depression, but the single-day schedule and the use of pre-treatment medications to enhance it are off-label. We discuss this openly during your consultation.
How long will I be at the clinic?
Plan on a full day, usually 10–11 hours including check-in, calibration, 20 sessions with breaks, and discharge.
What does a session feel like?
You'll hear clicking and feel a tapping sensation on your scalp. Mild headache or scalp discomfort is the most common side effect and usually fades within hours.
Do I need someone to drive me?
Yes. Because of the pre-treatment medication and the length of the day, please arrange a driver to take you home.
When will I feel better?
Some people notice changes within the first week, but improvement often builds gradually and may peak 4–6 weeks after treatment. Follow-up visits track your progress.
Can I keep taking my current medications?
In most cases, yes. Your psychiatrist reviews every medication beforehand and will tell you if anything needs to be adjusted or held.
What if it doesn't work, or symptoms come back?
Your psychiatrist will review next steps, which may include repeat treatment, Accelerated or Standard TMS, IV ketamine, or medication changes.
Does insurance cover ONE-Day TMS?
Mindspring Health is self-pay and does not bill insurance. Off-label TMS protocols are generally not covered by insurers. We can provide a superbill on request.
Interventional Psychiatry
Other options we offer
1–2 Week Protocol
Accelerated TMS
Multiple short sessions per day over 1–2 weeks.
Standard Daily Protocol
Standard rTMS
One session a day, the most-studied schedule.
In-Office Infusion
IV Ketamine Therapy
Medically supervised infusion series.
EEG-Guided Neurofeedback
PRISM for PTSD
Medication-free, FDA-cleared PTSD therapy.
Implantable Neuromodulation
VNS Therapy
Long-term option for treatment-resistant depression.
Find out if you're a candidate
Every interventional treatment at Mindspring Health starts with a comprehensive psychiatric evaluation by a board-certified psychiatrist.